A molecular determinant of phosphoinositide affinity in mammalian TRPV channels

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P(2) upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P(2) affinity in mammali...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Velisetty, Phanindra, Borbiro, Istvan, Kasimova, Marina A., Liu, Luyu, Badheka, Doreen, Carnevale, Vincenzo, Rohacs, Tibor
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904367/
https://ncbi.nlm.nih.gov/pubmed/27291418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27652
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