N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties

[Image: see text] A series of N1-azinylsulfonyl-3-(1,2,3,6,tetrahyrdopyridin-4-yl)-1H-indole derivatives was designed to obtain highly potent 5-HT(6) receptor ligands. The study allowed for the identification of 25 (4-{[5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-1-yl]sulfonyl}isoquinoline...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zajdel, Paweł, Marciniec, Krzysztof, Satała, Grzegorz, Canale, Vittorio, Kos, Tomasz, Partyka, Anna, Jastrzębska-Więsek, Magdalena, Wesołowska, Anna, Basińska-Ziobroń, Agnieszka, Wójcikowski, Jacek, Daniel, Władysława A., Bojarski, Andrzej J., Popik, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904269/
https://ncbi.nlm.nih.gov/pubmed/27326337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00056
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