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Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors

[Image: see text] Fibroblast growth factor receptors (FGFRs) are important targets for cancer therapy. Herein, we describe the design, synthesis, and biological evaluation of a novel series of 1H-pyrazolo[3,4-b]pyridine derivatives as potent and selective FGFR kinase inhibitors. On the basis of its...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Zhao, Bin, Li, Yixuan, Xu, Pan, Dai, Yang, Luo, Cheng, Sun, Yiming, Ai, Jing, Geng, Meiyu, Duan, Wenhu
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2016
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904267/
https://ncbi.nlm.nih.gov/pubmed/27326339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00066
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