Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors

Cystathionine β-synthase (CBS) is a key enzyme in the production of the signaling molecule hydrogen sulfide, deregulation of which is known to contribute to a range of serious pathological states. Involvement of hydrogen sulfide in pathways of paramount importance for cellular homeostasis renders CB...

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Publicado no:Molecules
Main Authors: Fantel, Anna-Maria, Myrianthopoulos, Vassilios, Georgoulis, Anastasios, Lougiakis, Nikolaos, Zantza, Iliana, Lamprinidis, George, Augsburger, Fiona, Marakos, Panagiotis, Vorgias, Constantinos E., Szabo, Csaba, Pouli, Nicole, Papapetropoulos, Andreas, Mikros, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465669/
https://ncbi.nlm.nih.gov/pubmed/32824311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163739
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