Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect

Recombinant human BMP-2 (rhBMP-2) is a potent osteoinductive agent, but has been associated not only with bone formation, but also osteoclastogenesis and bone resorption. Osteoprotegerin (OPG) is a RANKL inhibitor that blocks differentiation and function of osteoclasts. We hypothesized that the comb...

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Publicado no:Bone
Main Authors: Bougioukli, Sofia, Jain, Ashish, Sugiyama, Osamu, Tinsley, Brian A., Tang, Amy H., Tan, Matthew H., Adams, Douglas J., Kostenuik, Paul J., Lieberman, Jay R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4903101/
https://ncbi.nlm.nih.gov/pubmed/26723577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.12.052
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