Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System

Aurovertins are fungal polyketides that exhibit potent inhibition of ATP synthase. Aurovertins contain a 2,6-dioxabicyclo[3.2.1]-octane ring that is proposed to be derived from a polyene precursor through regioselective oxidations and epoxide openings. In this study, we identified only four enzymes...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Mao, Xu-Ming, Zhan, Zha-Jun, Grayson, Matthew N., Tang, Man-Cheng, Xu, Wei, Li, Yong-Quan, Yin, Wen-Bing, Lin, Hsiao-Ching, Chooi, Yit-Heng, Houk, K. N., Tang, Yi
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4903023/
https://ncbi.nlm.nih.gov/pubmed/26340065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07816
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