Molecular basis for multimerization in the activation of the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Huang, Yongjian, Bharill, Shashank, Karandur, Deepti, Peterson, Sean M, Marita, Morgan, Shi, Xiaojun, Kaliszewski, Megan J, Smith, Adam W, Isacoff, Ehud Y, Kuriyan, John
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2016
Предметы:
Biochemistry and Chemical Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902571/
https://ncbi.nlm.nih.gov/pubmed/27017828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14107
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы