Molecular basis for multimerization in the activation of the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that...

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Veröffentlicht in:eLife
Hauptverfasser: Huang, Yongjian, Bharill, Shashank, Karandur, Deepti, Peterson, Sean M, Marita, Morgan, Shi, Xiaojun, Kaliszewski, Megan J, Smith, Adam W, Isacoff, Ehud Y, Kuriyan, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902571/
https://ncbi.nlm.nih.gov/pubmed/27017828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14107
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