Molecular basis for multimerization in the activation of the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Huang, Yongjian, Bharill, Shashank, Karandur, Deepti, Peterson, Sean M, Marita, Morgan, Shi, Xiaojun, Kaliszewski, Megan J, Smith, Adam W, Isacoff, Ehud Y, Kuriyan, John
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902571/
https://ncbi.nlm.nih.gov/pubmed/27017828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14107
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados