Intracerebroventricular Infusion of the (Pro)renin Receptor Antagonist PRO20 Attenuates Deoxycorticosterone Acetate-Salt–Induced Hypertension

We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and the development of deoxycorticosterone acetate (DOCA)-salt hypertension. Here, we designed and developed an antagonistic peptide, PRO20, to block prorenin binding...

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Vydáno v:Hypertension
Hlavní autoři: Li, Wencheng, Sullivan, Michelle N., Zhang, Sheng, Worker, Caleb J., Xiong, Zhenggang, Speth, Robert C., Feng, Yumei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902274/
https://ncbi.nlm.nih.gov/pubmed/25421983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04458
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