Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes

Secreted by activated cells or passively released by damaged cells, extracellular HMGB1 is a prototypical damage-associated molecular pattern (DAMP) inflammatory mediator. During the course of developing extracorporeal approaches to treating injury and infection, we inadvertently discovered that hap...

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Publicado en:JCI Insight
Autores principales: Yang, Huan, Wang, Haichao, Levine, Yaakov A., Gunasekaran, Manoj K., Wang, Yongjun, Addorisio, Meghan, Zhu, Shu, Li, Wei, Li, Jianhua, de Kleijn, Dominique P.V., Olofsson, Peder S., Warren, H. Shaw, He, Mingzhu, Al-Abed, Yousef, Roth, Jesse, Antoine, Daniel J., Chavan, Sangeeta S., Andersson, Ulf, Tracey, Kevin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902170/
https://ncbi.nlm.nih.gov/pubmed/27294203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85375
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