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Curcumin inhibits HIV-1 by promoting Tat protein degradation
HIV-1 Tat is an intrinsically unfolded protein playing a pivotal role in viral replication by associating with TAR region of viral LTR. Unfolded proteins are degraded by 20S proteasome in an ubiquitin independent manner. Curcumin is known to activate 20S proteasome and promotes the degradation of in...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901322/ https://ncbi.nlm.nih.gov/pubmed/27283735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27539 |
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