Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin

A series of saponins and sapogenins from Medicago species were tested for their ability to bind and activate the nuclear receptor PPARγ by SPR experiments and transactivation assay, respectively. The SPR analysis proved to be a very powerful and fast technique for screening a large number of compoun...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Montanari, Roberta, Capelli, Davide, Tava, Aldo, Galli, Andrea, Laghezza, Antonio, Tortorella, Paolo, Loiodice, Fulvio, Pochetti, Giorgio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901321/
https://ncbi.nlm.nih.gov/pubmed/27283034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27658
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