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Update on Lynch syndrome genomics
Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6, and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of the most prevalent hereditary cancer syndromes in man and accounts for 1–3 % of unselected colorectal carcinomas and some 15 % of t...
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| Publicado no: | Fam Cancer |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901089/ https://ncbi.nlm.nih.gov/pubmed/26873718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-016-9882-8 |
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