Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors

Biased integration remains a key challenge for gene therapy based on lentiviral vector technologies. Engineering of next-generation lentiviral vectors targeting safe genomic harbors for insertion is therefore of high relevance. In a previous paper (Cai et al., 2014a), we showed the use of integrase-...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Cai, Yujia, Laustsen, Anders, Zhou, Yan, Sun, Chenglong, Anderson, Mads Valdemar, Li, Shengting, Uldbjerg, Niels, Luo, Yonglun, Jakobsen, Martin R, Mikkelsen, Jacob Giehm
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900802/
https://ncbi.nlm.nih.gov/pubmed/27278774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12213
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