Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs

Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xenogeneic antigens in humans, for example α1–3 Gala...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Reynard, Olivier, Jacquot, Frédéric, Evanno, Gwénaëlle, Mai, Hoa Le, Salama, Apolline, Martinet, Bernard, Duvaux, Odile, Bach, Jean-Marie, Conchon, Sophie, Judor, Jean-Paul, Perota, Andrea, Lagutina, Irina, Duchi, Roberto, Lazzari, Giovanna, Le Berre, Ludmilla, Perreault, Hélène, Lheriteau, Elsa, Raoul, Hervé, Volchkov, Viktor, Galli, Cesare, Soulillou, Jean-Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900587/
https://ncbi.nlm.nih.gov/pubmed/27280712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156775
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