Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism

C-type natriuretic peptide activation of guanylyl cyclase B (GC-B), also known as natriuretic peptide receptor B or NPR2, stimulates long bone growth, and missense mutations in GC-B cause dwarfism. Four such mutants (L658F, Y708C, R776W, and G959A) bound (125)I-C-type natriuretic peptide on the surf...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dickey, Deborah M., Edmund, Aaron B., Otto, Neil M., Chaffee, Thomas S., Robinson, Jerid W., Potter, Lincoln R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900282/
https://ncbi.nlm.nih.gov/pubmed/26980729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704015
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