Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE

Type 1 diabetes mellitus is caused by the killing of insulin-producing β cells by CD8+T cells. The disease progression, which is chronic, does not follow a course like responses to conventional antigens such as viruses, but accelerates as glucose tolerance deteriorates. To identify the unique featur...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Garyu, Justin W., Uduman, Mohamed, Stewart, Alex, Rui, Jinxiu, Deng, Songyan, Shenson, Jared, Staron, Matt M., Kaech, Susan M., Kleinstein, Steven H., Herold, Kevan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900270/
https://ncbi.nlm.nih.gov/pubmed/26994137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713362
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