Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance. Consistently, mice with null mutation of Ceacam1 (Cc1(−/−)) exhibit impaired insulin clearance with increased lipid production in liver and redistribution to white adipose tissue, leading to visce...

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Udgivet i:J Biol Chem
Main Authors: Heinrich, Garrett, Russo, Lucia, Castaneda, Tamara R., Pfeiffer, Verena, Ghadieh, Hilda E., Ghanem, Simona S., Wu, Jieshen, Faulkner, Latrice D., Ergün, Süleyman, McInerney, Marcia F., Hill, Jennifer W., Najjar, Sonia M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900262/
https://ncbi.nlm.nih.gov/pubmed/27002145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716431
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