αB-Crystallin Interacts with Na(v)1.5 and Regulates Ubiquitination and Internalization of Cell Surface Na(v)1.5

Na(v)1.5, the pore-forming α subunit of the cardiac voltage-gated Na(+) channel complex, is required for the initiation and propagation of the cardiac action potential. Mutations in Na(v)1.5 cause cardiac arrhythmias and sudden death. The cardiac Na(+) channel functions as a protein complex; however...

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Vydáno v:J Biol Chem
Hlavní autoři: Huang, Yuan, Wang, Zhijie, Liu, Yinan, Xiong, Hongbo, Zhao, Yuanyuan, Wu, Ling, Yuan, Chao, Wang, Longfei, Hou, Yuxi, Yu, Gang, Huang, Zhengrong, Xu, Chengqi, Chen, Qiuyun, Wang, Qing K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900253/
https://ncbi.nlm.nih.gov/pubmed/26961874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695080
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