Central Role and Mechanisms of β-Cell Dysfunction and Death in Friedreich Ataxia–Associated Diabetes

OBJECTIVE: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused in almost all cases by homozygosity for a GAA trinucleotide repeat expansion in the frataxin gene. Frataxin is a mitochondrial protein involved in iron homeostasis. FRDA patients have a high prevalence of...

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Publicado no:Ann Neurol
Main Authors: Cnop, Miriam, Igoillo-Esteve, Mariana, Rai, Myriam, Begu, Audrey, Serroukh, Yasmina, Depondt, Chantal, Musuaya, Anyishai E., Marhfour, Ihsane, Ladrière, Laurence, Lopez, Xavier Moles, Lefkaditis, Dionysios, Moore, Fabrice, Brion, Jean-Pierre, Cooper, J. Mark, Schapira, Anthony H. V., Clark, Anne, Koeppen, Arnulf H., Marchetti, Piero, Pandolfo, Massimo, Eizirik, Décio L., Féry, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900175/
https://ncbi.nlm.nih.gov/pubmed/23280845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23698
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