A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis

The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial hyperplasia and pathological neovascularization. Here we report that PPI-2458, a member of the fumagillin class of irreversible methionine aminopeptidase-2 (MetAP-2) inhib...

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Autors principals: Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC490009/
https://ncbi.nlm.nih.gov/pubmed/15249666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404105101
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