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A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis
The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial hyperplasia and pathological neovascularization. Here we report that PPI-2458, a member of the fumagillin class of irreversible methionine aminopeptidase-2 (MetAP-2) inhib...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC490009/ https://ncbi.nlm.nih.gov/pubmed/15249666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404105101 |
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