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Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Serum levels of the lipid mediator sphingosine-1-phosphate (S1P) are reduced in septic patients and are inversely associated with disease severity. We show that serum S1P is reduced in human sepsis and in murine models of sepsis. We then investigated whether pharmacological or genetic approaches tha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Coldewey, Sina M., Benetti, Elisa, Collino, Massimo, Pfeilschifter, Josef, Sponholz, Christoph, Bauer, Michael, Huwiler, Andrea, Thiemermann, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899780/
https://ncbi.nlm.nih.gov/pubmed/27277195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27594
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