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Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness

Codon usage adaptation of lytic viruses to their hosts is determinant for viral fitness. In this work, we analyzed the codon usage of adenoviral proteins by principal component analysis and assessed their codon adaptation to the host. We observed a general clustering of adenoviral proteins according...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Villanueva, Eneko, Martí-Solano, Maria, Fillat, Cristina
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899721/
https://ncbi.nlm.nih.gov/pubmed/27278133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27546
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