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Slow Fitness Recovery in a Codon-Modified Viral Genome
Extensive synonymous codon modification of viral genomes appears to be an effective way of attenuating strains for use as live vaccines. An assumption of this method is that codon changes have individually small effects, such that codon-attenuated viruses will be slow to evolve back to high fitness...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457771/ https://ncbi.nlm.nih.gov/pubmed/22532576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss119 |
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