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Establishing Virulence Associated Polyphosphate Kinase 2 as a drug target for Mycobacterium tuberculosis

Inorganic polyphosphate (PolyP) plays an essential role in microbial stress adaptation, virulence and drug tolerance. The genome of Mycobacterium tuberculosis encodes for two polyphosphate kinases (PPK-1, Rv2984 and PPK-2, Rv3232c) and polyphosphatases (ppx-1, Rv0496 and ppx-2, Rv1026) for maintenan...

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Foilsithe in:Sci Rep
Main Authors: Singh, Mamta, Tiwari, Prabhakar, Arora, Garima, Agarwal, Sakshi, Kidwai, Saqib, Singh, Ramandeep
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899718/
https://ncbi.nlm.nih.gov/pubmed/27279366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26900
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