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Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C
Higher affinity for TnI explains how troponin C (TnC) carrying a causative hypertrophic cardiomyopathy mutation, TnC(A8V), sensitizes muscle cells to Ca(2+). Muscle fibers reconstituted with TnC(A8V) require ~2.3-fold less [Ca(2+)] to achieve 50% maximum-tension compared to fibers reconstituted with...
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| Publicado no: | Arch Biochem Biophys |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899184/ https://ncbi.nlm.nih.gov/pubmed/26976709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.03.011 |
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