Insulin-Like Growth Factor 1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E Deficient Mice

BACKGROUND: We have previously shown that systemic infusion of insulin-like growth factor-1 (IGF-1) exerts anti-inflammatory and anti-oxidant effects and reduces atherosclerotic burden in apolipoprotein E (Apoe) deficient mice. Monocytes/macrophages express high levels of IGF-1 receptor (IGF1R) and...

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Publicado en:Circulation
Main Authors: Higashi, Yusuke, Sukhanov, Sergiy, Shai, Shaw-Yung, Danchuk, Svitlana, Tang, Richard, Snarski, Patricia, Li, Zhaohui, Lobelle-Rich, Patricia, Wang, Meifang, Wang, Derek, Yu, Hong, Korthuis, Ronald, Delafontaine, Patrice
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899151/
https://ncbi.nlm.nih.gov/pubmed/27154724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.021805
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