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Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities

A series of bis(indolyl)glyoxylamides 10a–n has been designed and synthesized. In situ generated indole-3-glyoxalylchloride from the reaction of readily available indole 9 with oxalyl chloride was treated with tryptamine to produce bis(indolyl)glyoxylamides 10a–n in 82–93% yields. All the synthesize...

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Dettagli Bibliografici
Pubblicato in:Bioorg Med Chem Lett
Autori principali: Tantak, Mukund P., Gupta, Vishakha, Nikhil, Kumar, Arun, V., Singh, Rajnish Prakash, Jha, Prabhat Nath, Shah, Kavita, Kumar, Dalip
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899133/
https://ncbi.nlm.nih.gov/pubmed/27173802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.04.080
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