Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening

Human testis-specific and bromodomain-containing protein (hBRDT) is essential for chromatin remodeling during spermatogenesis and is therefore an attractive target for the discovery of male contraceptive drugs. In this study, pharmacophore modeling was carried out based on the crystal structure of h...

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Publicado no:Int J Mol Med
Main Authors: GAO, NANA, REN, JIXIA, HOU, LI, ZHOU, YUE, XIN, LING, WANG, JIEDONG, YU, HEMING, XIE, YONG, WANG, HUIPING
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899012/
https://ncbi.nlm.nih.gov/pubmed/27220398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2016.2602
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