MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors such as ageing, obesity and trauma. Previously, it was reported that the inhibition of microRNA-34a (miR-34a) may reduce rat chondrocyte apoptosis induced by IL-1β, whereas the mo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Mol Med
Auteurs principaux: YAN, SHIJU, WANG, MENG, ZHAO, JIAN, ZHANG, HONGTAO, ZHOU, CHENGPEI, JIN, LEI, ZHANG, YINGLONG, QIU, XIUCHUN, MA, BAOAN, FAN, QINGYU
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899008/
https://ncbi.nlm.nih.gov/pubmed/27247228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2016.2618
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