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Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

Engineered protein therapeutics offer advantages, including strong target affinity, selectivity, and low toxicity, but like natural proteins can be susceptible to proteolytic degradation, thereby limiting their effectiveness. A compelling therapeutic target is mesotrypsin, a protease upregulated wit...

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Bibliografische gegevens
Gepubliceerd in:Biochem J
Hoofdauteurs: Cohen, Itay, Kayode, Olumide, Hockla, Alexandra, Sankaran, Banumathi, Radisky, Derek, Radisky, Evette, Papo, Niv
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898653/
https://ncbi.nlm.nih.gov/pubmed/26957636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151410
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