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Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
Engineered protein therapeutics offer advantages, including strong target affinity, selectivity, and low toxicity, but like natural proteins can be susceptible to proteolytic degradation, thereby limiting their effectiveness. A compelling therapeutic target is mesotrypsin, a protease upregulated wit...
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| Foilsithe in: | Biochem J |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4898653/ https://ncbi.nlm.nih.gov/pubmed/26957636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151410 |
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