Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

Engineered protein therapeutics offer advantages, including strong target affinity, selectivity, and low toxicity, but like natural proteins can be susceptible to proteolytic degradation, thereby limiting their effectiveness. A compelling therapeutic target is mesotrypsin, a protease upregulated wit...

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Bibliographic Details
Published in:Biochem J
Main Authors: Cohen, Itay, Kayode, Olumide, Hockla, Alexandra, Sankaran, Banumathi, Radisky, Derek, Radisky, Evette, Papo, Niv
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898653/
https://ncbi.nlm.nih.gov/pubmed/26957636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151410
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