Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

Fructose consumption induces metabolic syndrome to increase cardiovascular disease risk. Cinnamaldehyde and allopurinol possess anti-oxidative and anti-inflammatory activity to relieve heart injury in metabolic syndrome. But the mechanisms of fructose-induced cardiac injury, and cardioprotective eff...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Kang, Lin-Lin, Zhang, Dong-Mei, Ma, Chun-Hua, Zhang, Jian-Hua, Jia, Ke-Ke, Liu, Jia-Hui, Wang, Rong, Kong, Ling-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897702/
https://ncbi.nlm.nih.gov/pubmed/27270216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27460
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