CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

Rikkunshito (RKT), a Kampo medicine, has been reported to show an ameliorative effect on sustained hypophagia after novelty stress exposure in aged mice through serotonin 2C receptor (5-HT(2C)R) antagonism. We aimed to determine (1) whether the activation of anorexigenic neurons, corticotropin-relea...

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Vydáno v:Sci Rep
Hlavní autoři: Mogami, Sachiko, Sadakane, Chiharu, Nahata, Miwa, Mizuhara, Yasuharu, Yamada, Chihiro, Hattori, Tomohisa, Takeda, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897628/
https://ncbi.nlm.nih.gov/pubmed/27273195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27516
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