Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess

Fetoplacental glucocorticoid overexposure is a significant mechanism underlying fetal growth restriction and the programming of adverse health outcomes in the adult. Placental glucocorticoid inactivation by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a key role. We previously discovered...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wyrwoll, Caitlin S., Noble, June, Thomson, Adrian, Tesic, Dijana, Miller, Mark R., Rog-Zielinska, Eva A., Moran, Carmel M., Seckl, Jonathan R., Chapman, Karen E., Holmes, Megan C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896723/
https://ncbi.nlm.nih.gov/pubmed/27185937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520356113
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