Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation

Staphylococcus aureus is a major bacterial pathogen, which causes severe blood and tissue infections that frequently emerge by autoinfection with asymptomatically carried nose and skin populations. However, recent studies report that bloodstream isolates differ systematically from those found in the...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Das, Sudip, Lindemann, Claudia, Young, Bernadette C., Muller, Julius, Österreich, Babett, Ternette, Nicola, Winkler, Ann-Cathrin, Paprotka, Kerstin, Reinhardt, Richard, Förstner, Konrad U., Allen, Elizabeth, Flaxman, Amy, Yamaguchi, Yuko, Rollier, Christine S., van Diemen, Pauline, Blättner, Sebastian, Remmele, Christian W., Selle, Martina, Dittrich, Marcus, Müller, Tobias, Vogel, Jörg, Ohlsen, Knut, Crook, Derrick W., Massey, Ruth, Wilson, Daniel J., Rudel, Thomas, Wyllie, David H., Fraunholz, Martin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896717/
https://ncbi.nlm.nih.gov/pubmed/27185949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520255113
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