Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

Expression of the transcription factor Helios by Tregs ensures stable expression of a suppressive and anergic phenotype in the face of intense inflammatory responses, whereas Helios-deficient Tregs display diminished lineage stability, reduced FoxP3 expression, and production of proinflammatory cyto...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nakagawa, Hidetoshi, Sido, Jessica M., Reyes, Edwin E., Kiers, Valerie, Cantor, Harvey, Kim, Hye-Jung
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896716/
https://ncbi.nlm.nih.gov/pubmed/27185917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604765113
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