Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice

The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic r...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Reber, Stefan O., Siebler, Philip H., Donner, Nina C., Morton, James T., Smith, David G., Kopelman, Jared M., Lowe, Kenneth R., Wheeler, Kristen J., Fox, James H., Hassell, James E., Greenwood, Benjamin N., Jansch, Charline, Lechner, Anja, Schmidt, Dominic, Uschold-Schmidt, Nicole, Füchsl, Andrea M., Langgartner, Dominik, Walker, Frederick R., Hale, Matthew W., Lopez Perez, Gerardo, Van Treuren, Will, González, Antonio, Halweg-Edwards, Andrea L., Fleshner, Monika, Raison, Charles L., Rook, Graham A., Peddada, Shyamal D., Knight, Rob, Lowry, Christopher A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896712/
https://ncbi.nlm.nih.gov/pubmed/27185913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600324113
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