An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells

BACKGROUND: Glioblastoma (GBM) or grade IV astrocytoma is one of the most devastating human cancers. The loss of DFF40/CAD, the key endonuclease that triggers oligonucleosomal DNA fragmentation during apoptosis, has been linked to genomic instability and cell survival after radiation. Despite the ne...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Sánchez-Osuna, María, Martínez-Escardó, Laura, Granados-Colomina, Carla, Martínez-Soler, Fina, Pascual-Guiral, Sònia, Iglesias-Guimarais, Victoria, Velasco, Roser, Plans, Gerard, Vidal, Noemi, Tortosa, Avelina, Barcia, Carlos, Bruna, Jordi, Yuste, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896542/
https://ncbi.nlm.nih.gov/pubmed/26755073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov315
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