Caspase-activated DNase Is Necessary and Sufficient for Oligonucleosomal DNA Breakdown, but Not for Chromatin Disassembly during Caspase-dependent Apoptosis of LN-18 Glioblastoma Cells

Caspase-dependent apoptosis is a controlled type of cell death characterized by oligonucleosomal DNA breakdown and major nuclear morphological alterations. Other kinds of cell death do not share these highly distinctive traits because caspase-activated DNase (DFF40/CAD) remains inactive. Here, we re...

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Detalhes bibliográficos
Main Authors: Sánchez-Osuna, María, Garcia-Belinchón, Mercè, Iglesias-Guimarais, Victoria, Gil-Guiñón, Estel, Casanelles, Elisenda, Yuste, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081919/
https://ncbi.nlm.nih.gov/pubmed/24838313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550020
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