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Domain movements upon activation of phenylalanine hydroxylase characterized by crystallography and chromatography-coupled small-angle X-ray scattering

Mammalian phenylalanine hydroxylase (PheH) is an allosteric enzyme that catalyzes the first step in the catabolism of the amino acid phenylalanine. Following allosteric activation by high phenylalanine levels, the enzyme catalyzes the pterin-dependent conversion of phenylalanine to tyrosine. Inabili...

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Podrobná bibliografie
Vydáno v:J Am Chem Soc
Hlavní autoři: Meisburger, Steve P., Taylor, Alexander B., Khan, Crystal A., Zhang, Shengnan, Fitzpatrick, Paul F., Ando, Nozomi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896396/
https://ncbi.nlm.nih.gov/pubmed/27145334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b01563
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