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Arsenic Trioxide (ATO) cooperates with All Trans Retinoic Acid (ATRA) to enhance MAPK activation and differentiation in Human Myeloblastic Leukemia (HL-60) cells

Arsenic trioxide (ATO) synergistically promotes retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells, a PML-RARα negative cell line. In PML-RARα positive myeloid leukemia cells, ATO is known to cause degradation of PML-RARα with subsequent induced myeloid differentiation....

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Detalhes bibliográficos
Publicado no:Leuk Lymphoma
Main Authors: Nayak, Satyaprakash, Shen, Miaoqing, Varner, Jeffrey D., Yen, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896300/
https://ncbi.nlm.nih.gov/pubmed/20615082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2010.501535
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