Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury

Aims: Myocardial ischemia can result in marked mitochondrial damage leading to cardiac dysfunction, as such identifying novel mechanisms to limit mitochondrial injury is important. This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epox...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Akhnokh, Maria K., Yang, Feng Hua, Samokhvalov, Victor, Jamieson, Kristi L., Cho, Woo Jung, Wagg, Cory, Takawale, Abhijit, Wang, Xiuhua, Lopaschuk, Gary D., Hammock, Bruce D., Kassiri, Zamaneh, Seubert, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896112/
https://ncbi.nlm.nih.gov/pubmed/27375480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00133
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