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Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis

Prenyltransferase enzymes promote the membrane localization of their target proteins by directing the attachment of a hydrophobic lipid group at a conserved C-terminal CAAX motif. Subsequently, the prenylated protein is further modified by postprenylation processing enzymes that cleave the terminal...

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Pubblicato in:mSphere
Autori principali: Esher, Shannon K., Ost, Kyla S., Kozubowski, Lukasz, Yang, Dong-Hoon, Kim, Min Su, Bahn, Yong-Sun, Alspaugh, J. Andrew, Nichols, Connie B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894686/
https://ncbi.nlm.nih.gov/pubmed/27303728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00084-15
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