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FAT10 KNOCK OUT MICE LIVERS FAIL TO DEVELOP MALLORY-DENK BODIES IN THE DDC MOUSE MODEL
Mallory-Denk bodies (MDBs) are aggresomes composed of undigested ubiqutinated short lived proteins which have accumulated because of a decrease in the rate of their degradation by the 26s proteasome. The decrease in the activity of the proteasome is due to a shift in the activity of the 26s proteaso...
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| Izdano u: | Exp Mol Pathol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4894526/ https://ncbi.nlm.nih.gov/pubmed/22981937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2012.09.002 |
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