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FAT10 KNOCK OUT MICE LIVERS FAIL TO DEVELOP MALLORY-DENK BODIES IN THE DDC MOUSE MODEL

Mallory-Denk bodies (MDBs) are aggresomes composed of undigested ubiqutinated short lived proteins which have accumulated because of a decrease in the rate of their degradation by the 26s proteasome. The decrease in the activity of the proteasome is due to a shift in the activity of the 26s proteaso...

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Detalles Bibliográficos
Publicado en:Exp Mol Pathol
Main Authors: French, SW, French, BA, Oliva, J, Li, J, Bardag-Gorce, F, Tillman, B, Canaan, A
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894526/
https://ncbi.nlm.nih.gov/pubmed/22981937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2012.09.002
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