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The structural basis of an NADP(+)-independent dithiol oxidase in FK228 biosynthesis
The disulfide bond is unusual in natural products and critical for thermal stability, cell permeability and bioactivity. DepH from Chromobacterium violaceum No. 968 is an FAD-dependent enzyme responsible for catalyzing the disulfide bond formation of FK228, an anticancer prodrug approved for the tre...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4894451/ https://ncbi.nlm.nih.gov/pubmed/24553401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04145 |
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