Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor

The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR β-lactamase (Bla) reporter gen...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Hsu, Chia-Wen, Zhao, Jinghua, Huang, Ruili, Hsieh, Jui-Hua, Hamm, Jon, Chang, Xiaoqing, Houck, Keith, Xia, Menghang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894417/
https://ncbi.nlm.nih.gov/pubmed/25257666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06437
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