Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor

The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR β-lactamase (Bla) reporter gen...

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發表在:Sci Rep
Main Authors: Hsu, Chia-Wen, Zhao, Jinghua, Huang, Ruili, Hsieh, Jui-Hua, Hamm, Jon, Chang, Xiaoqing, Houck, Keith, Xia, Menghang
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894417/
https://ncbi.nlm.nih.gov/pubmed/25257666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06437
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